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KMID : 0371320000590050693
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Journal of the Korean Surgical Society
2000 Volume.59 No. 5 p.693 ~ p.698
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Alpha-Fetoprotein Producing Rectal Cancer -A case report-
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백승혁/Seung Hyuk Baik
김남규/민진식/김태승/Nam Kyu Kim/Jin Sik Min/Tai Seung Kim
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Abstract
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We experienced a case of a 38 year old women in whom an alpha-fetoprotein producing carcinoma originated in the rectum. The patient had symptoms of hematochezia and bowel habit change, and a rectal examination revealed an ulcerative mass at the
midrectum. The mass size was 6.5 cm?6 cm. The serum alpha-fetoprotein measured preoperatively was 9336 ng/ml, and the serum (carcinoembryonic antigen) was 6.4 ng/ml. The serum level of alpha-fetoprotein decreased to 830 ng/ml thirteen days after
a
low
anterior resection. The tumor mass was a poorly differentiated adenocarcinoma. Using an immunohistochemical staining method, we detected alpha-fetoprotein producing cells in the tumor mass. During the follow up, the serum alpha-fetoprotein level
began
to increase continuously, and an abdominopelvic CT scan showed a systemic, local tumor recurrence. Based on our experience with this patient and a review of the literature on the few cases previously reported, it seems that alpha-fetoprotein
producing
colorectal carcinamas have a tendency to produce frequent blood-borne metastasis and are associated with a poor prognosis.
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